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Nat Med. 2002 Sep;8(9):918-21.

A reevaluation of integrins as regulators of angiogenesis.

Author information

1
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. rohynes@mit.edu

Abstract

Pharmacological agents directed against the integrins alpha(v)beta(3) and alpha(v)beta(5) have been reported to inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail to block angiogenesis and in some cases even enhance it. This apparent paradox suggests the hypotheses that these integrins are negative regulators of angiogenesis and that the drugs targeting them may be acting as agonists rather than antagonists.

PMID:
12205444
DOI:
10.1038/nm0902-918
[Indexed for MEDLINE]

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