Abstract
During the present study, ethanol extracts of five seaweed species Solieria robusta, Iyengaria stellata, Colpomenia sinuosa, Spatoglossum asperum and Caulerpa racemosa at 10 mg/ 200 g body weight were tested for their hypolipidaemic activity. All the species significantly decreased the serum total cholesterol, triglyceride and low density lipoprotein cholesterol levels in normal, triton-induced and diet-induced hyperlipidaemic rats. Solieria robusta was found to be the most effective in reducing the lipid profile, particularly in diet-induced hyperlipidaemic rats. A beneficial effect of the ethanol extract of S. asperum was also found on cardiac and liver enzymes in diet-induced hyperlipidaemic rats.
Copyright 2002 John Wiley & Sons, Ltd.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Dietary Fats / pharmacology
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Disease Models, Animal
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Hyperlipidemias / blood
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Hyperlipidemias / chemically induced
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Hyperlipidemias / drug therapy
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Hyperlipidemias / metabolism
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Hypolipidemic Agents / administration & dosage
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Hypolipidemic Agents / pharmacology*
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Hypolipidemic Agents / therapeutic use
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Male
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Pakistan
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Polyethylene Glycols / administration & dosage
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Polyethylene Glycols / pharmacology
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Rats
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Seaweed / chemistry*
Substances
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Dietary Fats
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Hypolipidemic Agents
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Plant Extracts
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Polyethylene Glycols
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tyloxapol