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Am J Psychiatry. 2002 Sep;159(9):1593-5.

Association of risperidone treatment response with a polymorphism in the 5-HT(2A) receptor gene.

Author information

1
Department of Psychiatry, Tzu-Chi General Hospital, Institute of Neuroscience, Tzu-Chi University, Hualien City, Taiwan.

Abstract

OBJECTIVE:

This study investigated the effect of the 102-T/C polymorphism in the 5-HT(2A) receptor gene on risperidone efficacy.

METHOD:

One hundred Han Chinese patients with acutely exacerbated schizophrenia were given risperidone for up to 42 days. The patients were genotyped for 5-HT(2A) polymorphisms. Psychopathology was measured biweekly with the Positive and Negative Syndrome Scale while the patients were taking risperidone. Generalized estimating equation methods were used to analyze the effects of treatment duration, T/C genotypes, and other prognostic factors on Positive and Negative Syndrome Scale performance.

RESULTS:

Patients with the C/C genotype had lower total scores, negative subscale scores, and general psychopathology scores but not positive subscale scores on the Positive and Negative Syndrome Scale than patients with the 102-T/C genotype. Patients with the T/C and T/T genotypes had comparable total and subscale scores. The number of previous hospitalizations and the dose of risperidone also affected Positive and Negative Syndrome Scale total scores.

CONCLUSIONS:

These results suggest that variations in the 5-HT(2A) receptor gene may influence individual responses to risperidone.

PMID:
12202283
DOI:
10.1176/appi.ajp.159.9.1593
[Indexed for MEDLINE]
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