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Cell. 2002 Aug 23;110(4):407-13.

Shared strategies in gene organization among prokaryotes and eukaryotes.

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Department of Biological Sciences, University of Pittsburgh, PA 15260, USA.


Although genes in prokaryotes and eukaryotes are transcribed and translated by very different mechanisms, they may be organized in their respective chromosomes in surprisingly similar ways. Here, I examine common modes of maintaining nonrandom gene organization in both prokaryotes and eukaryotes, the different ways these organizations have likely arisen, and classes of organization that may be unique to one group or the other.

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