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Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12391-6. Epub 2002 Aug 28.

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae.

Author information

1
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA.

Abstract

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.

PMID:
12200547
PMCID:
PMC129455
DOI:
10.1073/pnas.182380799
[Indexed for MEDLINE]
Free PMC Article

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