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J Affect Disord. 2002 Nov;72(2):177-84.

Defining remission by cut off score on the MADRS: selecting the optimal value.

Author information

1
Department of Psychiatry, QEII Hospital, Hertfordshire AL7 4HQ, Welwyn Garden City, UK. c.l.hawley@herts.ac.uk

Abstract

BACKGROUND:

Remission from major depression may be conceptualised in terms of a cut-off score on an appropriate rating scale. Candidate values proposed hitherto have not been directly validated.

METHOD:

The relationship between The Clinical Global Impression Scale for Severity (CGI-S) and the Montgomery-Asberg Depression Rating Scale (MADRS) was explored in 684 major depressed patients (1114 observations). The value on the MADRS which had greatest concordance with remission, as defined by the CGI-S, was computed using two models. Concordance between clinician and patient judgements of global illness were also compared.

RESULTS AND CONCLUSION:

The two models yielded optimal definitions of remission of <9 and <10 on the MADRS. Either value offers a workable operationalisation of remission and there is little to choose between them.

CLINICAL RELEVANCE:

The data confirm that MADRS <10 should provide the clinician with a valid, and reasonably objectifiable, target for remission

PMID:
12200208
DOI:
10.1016/s0165-0327(01)00451-7
[Indexed for MEDLINE]

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