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Curr Opin Genet Dev. 2002 Oct;12(5):601-6.

Decoding cis-regulatory DNAs in the Drosophila genome.

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Department of Molecular Cell Biology, Division of Genetics & Development, 401 Barker Hall, University of California, Berkeley, California 94720, USA.


Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.

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