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Curr Opin Genet Dev. 2002 Oct;12(5):572-82.

Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries.

Author information

1
Department of Zoology, University of Toronto, 25 Harbord Street, Ontario M5S 3G5, Toronto, Canada. utepass@zoo.utoronto.ca

Abstract

The organisation of the animal body into distinct tissues requires adhesive mechanisms that promote and maintain the physical segregation, the sorting, of different cell populations. Signals that control differential cell affinities across tissue boundaries have been identified, including Hedgehog, Notch, and EGF receptor signalling. Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility.

PMID:
12200163
DOI:
10.1016/s0959-437x(02)00342-8
[Indexed for MEDLINE]

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