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Curr Opin Genet Dev. 2002 Oct;12(5):512-8.

Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

Author information

1
MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK. sin@mrc-lmb.cam.ac.uk

Abstract

Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

PMID:
12200155
DOI:
10.1016/s0959-437x(02)00334-9
[Indexed for MEDLINE]

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