Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2002 Sep;23(9):445-9.

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

Author information

1
University of Erlangen, Department of Dermatology, Hartmannstr. 14, 91052 Erlangen, Germany. lutz@derma.imed.uni-erlangen.de

Abstract

Dendritic cells (DCs) are currently divided into tolerogenic immature and immunogenic mature differentiation stages. However, recent findings challenge this model by reporting mature DCs as inducers of regulatory CD4+ T cells in vivo. This implies that decisive tolerogenic and immunogenic maturation signals for DCs might exist. Closer inspection reveals that tolerance is observed when partial- or semi-maturation of DCs occurs, whereas only full DC maturation is immunogenic. The decisive immunogenic signal seems to be the release of proinflammatory cytokines from the DCs. Moreover, the semi-mature DC phenotype is comparable to steady-state migratory veiled DCs within the lymphatics, which seem to continuously tolerize lymph node T cells against tissue-derived self-antigens or apoptotic cells.

Comment in

PMID:
12200066
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center