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Mol Immunol. 2002 Oct;39(3-4):165-9.

The role of the proteasome activator PA28 in MHC class I antigen processing.

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Institut für Biochemie, Charité-Medizinische Fakültät der, Humboldt Universität zu Berlin, Monbijoustrasse 2, 10117 Berlin, Germany.


The proteasome system is the major source for the generation of viral antigens and tumor antigens presented by major histocompatibility complex class I (MHC class I) molecules. A specific feature of the proteasomal antigen processing machinery is that five of its components are inducible by IFN-gamma. Two of these are the alpha and beta subunits of the proteasome activator PA28. Our results show that PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen.

[Indexed for MEDLINE]

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