Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Biochem Cell Biol. 2002 Nov;34(11):1491-5.

LAG1 puts the focus on ceramide signaling.

Author information

1
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7-2, New Orleans, LA 70112, USA. sjazwi@1suhsc.edu

Abstract

Longevity-assurance gene 1 (LAG 1) is a yeast longevity gene. Homologues of the Lag 1 protein can be found throughout phylogeny, although sequence similarity is very limited. The Lag 1 protein is located in the endoplasmic reticulum (ER), where it helps to accelerate the transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi. This function of Lag 1 p results from its participation in ceramide synthesis. Thus, Lag 1 p and its homologues are likely to play a role in ceramide signaling, which affects growth, proliferation, stress resistance, and apoptosis. This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span.

PMID:
12200041
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center