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Int J Biochem Cell Biol. 2002 Nov;34(11):1491-5.

LAG1 puts the focus on ceramide signaling.

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Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7-2, New Orleans, LA 70112, USA.


Longevity-assurance gene 1 (LAG 1) is a yeast longevity gene. Homologues of the Lag 1 protein can be found throughout phylogeny, although sequence similarity is very limited. The Lag 1 protein is located in the endoplasmic reticulum (ER), where it helps to accelerate the transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi. This function of Lag 1 p results from its participation in ceramide synthesis. Thus, Lag 1 p and its homologues are likely to play a role in ceramide signaling, which affects growth, proliferation, stress resistance, and apoptosis. This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span.

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