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Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):38S-43S.

Ethanol-induced Cas tyrosine phosphorylation and Fyn kinase activation in rat brain.

Author information

1
Department of Legal Medicine, Osaka Medical College, Daigaku, Takatsuki, Japan.

Abstract

BACKGROUND:

Tyrosine phosphorylation signaling has been reported to be involved in regulatory mechanisms of ethanol-induced modulation of the central nervous system.

METHODS:

We investigated the effect of ethanol administration on tyrosine phosphorylation signaling in rat brain and also examined the possible involvement of Fyn kinase in the process.

RESULTS:

Immunoprecipitation experiments showed that Crk-associated substrate (Cas) was tyrosine-phosphorylated in response to ethanol administration. Fyn kinase was shown to be activated by ethanol administration and to phosphorylate Cas on tyrosine residue in vitro. Furthermore, Fyn kinase was co-localized with Cas in rat cerebellum and cerebral cortex.

CONCLUSIONS:

Cas was tyrosine-phosphorylated in rat brain by ethanol administration, and Fyn kinase was most likely involved in the process.

[Indexed for MEDLINE]

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