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Am J Hum Genet. 2002 Oct;71(4):695-714. Epub 2002 Aug 26.

Neocentromeres: role in human disease, evolution, and centromere study.

Author information

1
Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.

Abstract

The centromere is essential for the proper segregation and inheritance of genetic information. Neocentromeres are ectopic centromeres that originate occasionally from noncentromeric regions of chromosomes. Despite the complete absence of normal centromeric alpha-satellite DNA, human neocentromeres are able to form a primary constriction and assemble a functional kinetochore. Since the discovery and characterization of the first case of a human neocentromere in our laboratory a decade ago, 60 examples of constitutional human neocentromeres distributed widely across the genome have been described. Typically, these are located on marker chromosomes that have been detected in children with developmental delay or congenital abnormalities. Neocentromeres have also been detected in at least two types of human cancer and have been experimentally induced in Drosophila. Current evidence from human and fly studies indicates that neocentromere activity is acquired epigenetically rather than by any alteration to the DNA sequence. Since human neocentromere formation is generally detrimental to the individual, its biological value must lie beyond the individual level, such as in karyotype evolution and speciation.

PMID:
12196915
PMCID:
PMC378529
DOI:
10.1086/342730
[Indexed for MEDLINE]
Free PMC Article

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