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Neurology. 2002 Aug 27;59(4):639-41.

Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome.

Author information

1
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Hypocretin-1 levels were increased in evening CSF samples from subjects with restless legs syndrome, indicating altered hypocretin transmission in this sleep disorder. Increases in CSF hypocretin-1 levels were most striking in patients with early-onset restless legs syndrome.

PMID:
12196669
[Indexed for MEDLINE]

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