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Biochem Soc Trans. 2002 Aug;30(4):643-5.

Current understanding of the function of magnesium chelatase.

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Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.


Despite the global significance of chlorophylls and other modified tetrapyrroles, many aspects of their biosynthetic pathways are poorly understood. A key enzyme at the branch point between the haem and chlorophyll pathways, magnesium chelatase, couples the free energy of ATP hydrolysis to the insertion of magnesium into porphyrin, a process that is likely to be mediated through protein conformational changes. Conclusions from recent structural and functional studies of individual subunits are combined to provide a mechanistic outline of the full magnesium chelatase complex. Gathering further information presents a considerable challenge, and recent steps towards this goal will be introduced.

[Indexed for MEDLINE]

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