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Nat Prod Rep. 2002 Aug;19(4):477-93.

Oxidizing species in the mechanism of cytochrome P450.

Author information

1
Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446, USA. ortiz@cgl.ucsf.edu

Abstract

This review discusses the mechanisms of oxygen activation by cytochrome P450 enzymes, the possible catalytic roles of the various iron--oxygen species formed in the catalytic cycle, and progress in understanding the mechanisms of hydrocarbon hydroxylation, heteroatom oxidation, and olefin epoxidation. The focus of the review is on recent results, but earlier work is discussed as appropriate. The literature through to February 2002 is surveyed, and 175 referenced are cited.

PMID:
12195813
[Indexed for MEDLINE]

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