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Nat Neurosci. 2002 Sep;5(9):833-4.

Differential regulation of synaptic and extra-synaptic NMDA receptors.

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1
Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Abstract

A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown--the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.

PMID:
12195433
DOI:
10.1038/nn912
[Indexed for MEDLINE]
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