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J Hypertens. 2002 Sep;20(9):1873-8.

Effect of orlistat-induced weight loss on blood pressure and heart rate in obese patients with hypertension.

Author information

1
Franz-Volhard Klinik - Charité, Berlin, Germany and Teaching Diabetic Division, University Hospital Geneva, Switzerland. sharma@fvk-berlin.de

Abstract

OBJECTIVE:

To investigate the effects of long-term weight management with orlistat on blood pressure in obese hypertensive patients.

DESIGN:

A meta-analysis of data from five multicenter, randomized, placebo-controlled studies, conducted in Europe and the USA, was performed.

PATIENTS:

Obese adults [body mass index (BMI) 28-43 kg/m(2) ] with uncontrolled diastolic hypertension or isolated systolic hypertension (ISH) were eligible for inclusion.

INTERVENTIONS:

Following a 4-week placebo lead-in period, patients were randomized to orlistat 120 mg or placebo three times daily, in conjunction with a mildly reduced calorie diet for 1 year.

MAIN OUTCOME MEASURES:

Change in body weight was the primary efficacy parameter. Blood pressure, heart rate and systolic workload were assessed as secondary efficacy parameters.

RESULTS:

A total of 628 patients were included in the intent-to-treat (ITT) analysis. After 56 weeks, orlistat-treated patients had lost significantly more body weight than placebo recipients (8.0 versus 4.0%; P<0.001). Among patients with ISH, mean systolic pressure was reduced to a significantly greater degree after 1 year with orlistat compared to placebo (-9.4 versus -4.6 mmHg; P= 0.022). Similarly, reductions in mean diastolic pressure in patients with diastolic hypertension were greater with orlistat than with placebo (-7.7 versus -5.6 mmHg; P= 0.017). Weight loss of >or= 10% was associated with significant reductions in blood pressure, heart rate and systolic workload.

CONCLUSIONS:

Orlistat promotes clinically meaningful weight loss that is associated with significant reductions in blood pressure and heart rate, and may therefore have a role in the management of hypertension in overweight and obese patients.

PMID:
12195131
[Indexed for MEDLINE]

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