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Dev Cell. 2002 Aug;3(2):155-6.

Numb: "Adapting" notch for endocytosis.

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Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Houston, TX 77030, USA.


During sensory organ precursor divisions in Drosophila, the numb gene product segregates asymmetrically into one of the two daughter cells, to which it confers a specific fate by inhibiting Notch signaling. In this issue of Developmental Cell, Berdnik et al. show that Numb recruits alpha-Adaptin and that this physical interaction plays a role in downregulating Notch, presumably by stimulating endocytosis of Notch.

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