Format

Send to

Choose Destination
Neuroscientist. 2002 Aug;8(4):297-301.

Calcium dysregulation in the aging brain.

Author information

1
University of Kentucky, College of Medicine, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA. Tfoster@pop.uky.edu

Abstract

The idea that age-related cognitive decline is associated with disruption of calcium (Ca2+) homeostasis has been investigated over the past two decades. Much of this work has focused on the hippocampus because hippocampal-dependent memory is age sensitive. It is now well established that Ca(2+)-dependent processes such as susceptibility to neurotoxicity, the afterhyperpolarization amplitude, induction of synaptic plasticity, and long-term potentiation and long-term depression are altered with age. Recent work has identified changes in Ca2+ signaling pathways that may underlie the development of these biological markers of aging. This review considers recent findings concerning interactions between the various Ca(2+)-dependent processes, with special emphasis on the role of altered Ca2+ regulation and disruption of Ca2+ signaling pathways in mediating the expression of biological and behavioral markers of brain aging.

PMID:
12194497
DOI:
10.1177/107385840200800404
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center