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Eur J Neurosci. 2002 Aug;16(3):395-8.

Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy.

Author information

1
Department of Psychiatry, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA. mdavis4@emory.edu

Abstract

Infusions into the amygdala (a brain area essential for excitatory fear conditioning) of either NMDA receptor antagonists or inhibitors of the NMDA receptor-linked mitogen activated protein kinase cascade block extinction learning. Conversely, the NMDA receptor agonist D-cycloserine facilitates extinction after either systemic administration or intra-amygdala infusion. Because therapeutic interventions based on extinction procedures are commonly used to treat fear disorders, and because D-cycloserine is a widely available and safe compound, D-cycloserine or similar agents might be usefully combined with traditional extinction-based approaches in the treatment of clinical fear.

PMID:
12193180
[Indexed for MEDLINE]

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