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Eur J Neurosci. 2002 Aug;16(3):395-8.

Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy.

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Department of Psychiatry, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA.


Infusions into the amygdala (a brain area essential for excitatory fear conditioning) of either NMDA receptor antagonists or inhibitors of the NMDA receptor-linked mitogen activated protein kinase cascade block extinction learning. Conversely, the NMDA receptor agonist D-cycloserine facilitates extinction after either systemic administration or intra-amygdala infusion. Because therapeutic interventions based on extinction procedures are commonly used to treat fear disorders, and because D-cycloserine is a widely available and safe compound, D-cycloserine or similar agents might be usefully combined with traditional extinction-based approaches in the treatment of clinical fear.

[Indexed for MEDLINE]

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