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J Nat Prod. 2002 Aug;65(8):1216-8.

Two new triterpenoids from Azadirachta indica and their insecticidal activity.

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H.E.J. Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Pakistan.


Two new triterpenoids, 22,23-dihydronimocinol (1) and desfurano-6alpha-hydroxyazadiradione (2), were isolated from a methanolic extract of the fresh leaves of Azadirachta indica (neem) along with a known meliacin, 7alpha-senecioyl-(7-deacetyl)-23-O-methylnimocinolide. The structures of 1 and 2 were elucidated through spectral and chemical studies. Compounds 1 and 2 showed mortality for fourth instar larvae of the mosquito (Anopheles stephensi), with LC(50) values of 60 and 43 ppm, respectively.

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