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Funct Integr Genomics. 2002 Sep;2(4-5):199-211. Epub 2002 May 31.

Yeast and drug discovery.

Author information

1
Banting and Best Department of Medical Research, University of Toronto, 112 College St., Toronto, ON M5G 1L6, Canada. t.hughes@utoronto.ca

Abstract

Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast have been in widespread use less than a decade - a period shorter than the typical cycle from target identification to marketing approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds have yet to be realized.

PMID:
12192593
DOI:
10.1007/s10142-002-0059-1
[Indexed for MEDLINE]

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