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Nature. 2002 Aug 22;418(6900):837-8.

Rapid renewal of auditory hair bundles.

Abstract

Stereocilia, also known as hair bundles, are mechanosensitive organelles of the sensory hair cells of the inner ear that can detect displacements on a nanometre scale and are supported by a rigid, dense core of actin filaments. Here we show that these actin-filament arrays are continuously remodelled by the addition of actin monomers to the stereocilium tips, and that the entire core of the stereocilium is renewed every 48 hours. This unexpected dynamic feature of stereocilia will help our understanding of how auditory sensory function develops and is maintained.

PMID:
12192399
DOI:
10.1038/418837a
[Indexed for MEDLINE]

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