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Biochim Biophys Acta. 2002 Sep 2;1592(1):97-105.

Import and assembly of proteins into mitochondria of mammalian cells.

Author information

1
Department of Biochemistry, La Trobe University, , Melbourne 3086, Australia. N.Hoogenraad@latrobe.edu.au

Abstract

Most of our knowledge regarding the process of protein import into mitochondria has come from research employing fungal systems. This review outlines recent advances in our understanding of this process in mammalian cells. In particular, we focus on the characterisation of cytosolic molecular chaperones that are involved in binding to mitochondrial-targeted preproteins, as well as the identification of both conserved and novel subunits of the import machineries of the outer and inner mitochondrial membranes. We also discuss diseases associated with defects in import and assembly of mitochondrial proteins and what is currently known about the regulation of import in mammals.

PMID:
12191772
DOI:
10.1016/s0167-4889(02)00268-9
[Indexed for MEDLINE]
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