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Curr Cancer Drug Targets. 2001 May;1(1):73-83.

Drug target discovery by gene expression analysis: cell cycle genes.

Author information

1
Incyte Genomics and Department of Medicine, Stanford University, 1475 Flamingo Way, Sunnyvale, CA, USA. mwalker@stanfordalumni.org

Abstract

Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drug's mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.

PMID:
12188893
DOI:
10.2174/1568009013334241
[Indexed for MEDLINE]

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