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Trends Endocrinol Metab. 2002 Jul;13(5):220-5.

To ERR in the estrogen pathway.

Author information

1
McGill University Health Center, 687 Pine Avenue West, Montréal, Québec, Canada H3A 1A1. vgiguere@dir.molonc.mcgill.ca

Abstract

Estrogens control a variety of physiological and disease-linked processes, most notably reproduction, bone remodeling and breast cancer, and their effects are transduced through classic unclear receptors referred to as estrogen receptor-alpha (ER alpha) and ER beta. Recent results obtained using the estrogen-related receptors (ERR alpha, -beta and -gamma), a subfamily of orphan nuclear receptors closely related to the ERs, have shown that the ERRs share target genes, coregulatory proteins, ligands and sites of action with the ERs. In addition, the ERRs can actively influence the estrogenic response, suggesting that pharmacological modulation of ERR activity will be clinically useful to prevent and/or treat a variety of conditions related to women's health.

PMID:
12185669
[Indexed for MEDLINE]

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