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J Clin Gastroenterol. 2002 Jul;35(1 Suppl):S2-6.

Evolving concepts in the pathophysiology of functional gastrointestinal disorder.

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  • 1Division of Gastroenterology, Room 4W8A, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.


Functional gastrointestinal disorder (FGID) is common and may affect any part of the digestive tract from the esophagus to the rectum. Functional dyspepsia and the irritable bowel syndrome (IBS) are the most commonly recognized and until recently were considered distinct entities. In recent years, however, new observations and studies of the afferent nervous system have extended our concepts of both IBS and dyspepsia and suggest that these conditions may have common triggers and expression from similar pathophysiological processes.

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