Abstract
The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Actinobacillus Infections / etiology
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Actinobacillus Infections / immunology*
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Actinobacillus Infections / pathology*
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Aggregatibacter actinomycetemcomitans / pathogenicity*
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Alveolar Bone Loss / etiology
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Alveolar Bone Loss / immunology*
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Alveolar Bone Loss / pathology*
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Animals
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Carrier Proteins / metabolism*
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Chimera
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Cytokines / genetics
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Cytokines / metabolism*
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Female
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Gene Expression
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Humans
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Leukocyte Transfusion
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Membrane Glycoproteins / metabolism*
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Mice
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Mice, Inbred NOD
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Mice, SCID
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Periodontitis / etiology
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Periodontitis / immunology*
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Periodontitis / pathology*
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RANK Ligand
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Receptor Activator of Nuclear Factor-kappa B
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Th1 Cells / immunology
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Th2 Cells / immunology
Substances
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Carrier Proteins
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Cytokines
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Membrane Glycoproteins
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RANK Ligand
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Receptor Activator of Nuclear Factor-kappa B
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TNFRSF11A protein, human
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TNFSF11 protein, human
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Tnfrsf11a protein, mouse
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Tnfsf11 protein, mouse