Mixed periodontal Th1-Th2 cytokine profile in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)- mediated alveolar bone destruction in vivo

Infect Immun. 2002 Sep;70(9):5269-73. doi: 10.1128/IAI.70.9.5269-5273.2002.

Abstract

The Th1/Th2 cytokines involved in human periodontitis remain unclear; therefore, we established a humanized mouse model to investigate this issue in Actinobacillus actinomycetemcomitans-mediated periodontal infection. Quantitative-PCR analysis clearly demonstrates a predominantly mixed Th1 and Th2 expression profile associated with pathogen-specific cell-mediated immunity via osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actinobacillus Infections / etiology
  • Actinobacillus Infections / immunology*
  • Actinobacillus Infections / pathology*
  • Aggregatibacter actinomycetemcomitans / pathogenicity*
  • Alveolar Bone Loss / etiology
  • Alveolar Bone Loss / immunology*
  • Alveolar Bone Loss / pathology*
  • Animals
  • Carrier Proteins / metabolism*
  • Chimera
  • Cytokines / genetics
  • Cytokines / metabolism*
  • Female
  • Gene Expression
  • Humans
  • Leukocyte Transfusion
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Periodontitis / etiology
  • Periodontitis / immunology*
  • Periodontitis / pathology*
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • Th1 Cells / immunology
  • Th2 Cells / immunology

Substances

  • Carrier Proteins
  • Cytokines
  • Membrane Glycoproteins
  • RANK Ligand
  • Receptor Activator of Nuclear Factor-kappa B
  • TNFRSF11A protein, human
  • TNFSF11 protein, human
  • Tnfrsf11a protein, mouse
  • Tnfsf11 protein, mouse