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Cancer Res. 2002 Aug 15;62(16):4575-8.

Telomerase is regulated by c-Jun NH2-terminal kinase in ovarian surface epithelial cells.

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University of South Florida and the H. Lee Moffitt Cancer Center, Tampa, Florida 33612, USA.


Telomerase activity is present in >90% of all tumors and appears to be regulated by the phosphatidylinositol 3-kinase signaling pathway. Here we demonstrate that Akt is not involved in the signaling cascade for telomerase regulation in ovarian surface epithelial cells. However, we showed that c-Jun NH2-kinase induces telomerase activity, that inhibition of JNK by JIP abrogates telomerase activity, and that JNK expression activates transcription of a reporter gene fused to the hTERT promoter sequence. Consequently, our data show that JNK is a key regulator of telomerase activity and, hence, may provide new perspectives on tumorigenesis that could be exploited for novel therapeutic strategies.

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