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Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60.

Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro.

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1
Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria 3051, Australia.

Abstract

The phenylpropenamide derivatives AT-61 and AT-130 are nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. They inhibited the replication of wild-type HBV with 50% inhibitory concentrations of 21.2 +/- 9.5 and 2.40 +/- 0.92 micro M, respectively, compared to 0.064 +/- 0.020 micro M lamivudine. There were no significant differences in sensitivity between wild-type and nucleoside analogue-resistant (rtL180M, rtM204I, and rtL180M + rtM204V) HBV.

PMID:
12183271
PMCID:
PMC127422
[Indexed for MEDLINE]
Free PMC Article
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