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Curr Opin Plant Biol. 2002 Oct;5(5):444-51.

RNA silencing: small RNAs as ubiquitous regulators of gene expression.

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  • 1The Sainsbury Laboratory, John Innes Centre, Colney, Norwich NR4 7UH, UK.


'RNA silencing' is the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by RNA. Initially identified as an immune system that is targeted against transposons and viruses, RNA silencing is emerging as a fundamental regulatory process that is likely to affect many layers of endogenous gene expression in most, if not all, eukaryotes.

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