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Curr Opin Immunol. 2002 Oct;14(5):652-9.

Immunotherapy of insulin-dependent diabetes mellitus.

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UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.


Type 1 diabetes mellitus is caused by the T cell mediated autoimmune destruction of insulin-producing beta cells of the islets of Langerhans within the pancreas. Current immunotherapy strategies are aimed at directly inactivating the autoreactive T cells and/or inducing T cells with regulatory capabilities. At the preclinical level, several strategies that employ TCR antagonists -- including monoclonal antibodies, autoantigen-specific peptides and soluble TCR ligands -- are showing promise and being developed for clinical application. Several of these approaches employing monoclonal antibodies against the TCR-CD3 complex or soluble peptide antigens are producing favorable results in the clinic.

[Indexed for MEDLINE]

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