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Curr Opin Immunol. 2002 Oct;14(5):609-14.

Disease consequences of pathogen adaptation.

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Department of Biology, University of Utah, 257 South 1400 East, Salt Lake, UT 84112, USA.


Experimental evolution studies demonstrate that pathogens evolve rapidly, have a large capacity for increased virulence and cause disease in many different ways. A large proportion of genetic diversity for host susceptibility to infectious, autoimmune and 'genetic' diseases, and to cancer, is probably caused by pathogens and/or host counteradaptations. Recent advances in diverse fields support this claim and suggest many underused approaches for identifying and experimentally dissecting the complicated host-pathogen interactions that often lead to disease.

[Indexed for MEDLINE]

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