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Epilepsia. 2002 Aug;43(8):932-5.

Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold.

Author information

1
Department of Neurology University of California, San Francisco, San Francisco, California, U.S.A. karkark@itsa.ucsf.edu

Abstract

PURPOSE:

Focal cerebral cooling has been shown to reduce epileptiform activity in animals. There are, however, few reports of this phenomenon in humans.

METHODS:

Electrocorticography was performed before resection of a right frontal tumor in a patient with partial seizures. Cold saline was applied to the interictal spike focus, and its effect on the epileptiform discharges was observed.

RESULTS:

Application of cold saline to the spike focus resulted in a transient, complete cessation of spiking. This effect was reproduced with a second application of cold saline. The motor threshold for electrical stimulation remained unchanged during the application of saline.

CONCLUSIONS:

In this patient with tumor-related epilepsy, focal cooling of the cortex reproducibly abolished interictal epileptiform discharges without changing the motor threshold to electrical stimulation.

PMID:
12181015
[Indexed for MEDLINE]
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