Format

Send to

Choose Destination
Curr Biol. 2002 Jul 23;12(14):R499-R501.

Casein kinase 1: a Wnt'er of disconnect.

Author information

1
Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ppolakis@gene.com

Abstract

Phosphorylation of beta-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes beta-catenin for subsequent phophorylation by glycogen synthase kinase 3.

PMID:
12176352
DOI:
10.1016/s0960-9822(02)00969-7
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center