Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2002 Aug 9;110(3):277-80.

LINE drive. retrotransposition and genome instability.

Author information

  • 1Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA.


The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.

[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center