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Arch Biochem Biophys. 2002 Sep 1;405(1):73-77.

An investigation of the ionophoric characteristics of destruxin A.

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Centre for Molecular Design, University of Portsmouth, Portsmouth, Portsmouth, PO1 2DT, UK.


Destruxin A, a cyclohexadepsipeptide related to the enniatins and beauvericin, exhibits ionophoric properties. Calcium ion mobilization across liposomal membrane barriers, for example, has been demonstrated using the calcium ion-sensitive dyes Arsenazo III and Fura-2. Initial molecular mechanics/molecular dynamics calculations indicate the potential for destruxin A to form a coordination complex with calcium in which the divalent cation is bound at the center of a sandwich formed by two molecules of destruxin A. This novel calcium ion binding may help explain the diverse biological effects exhibited by the destruxins.

[Indexed for MEDLINE]

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