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J Am Chem Soc. 2002 Aug 21;124(33):9704-5.

Structural constraints from proton-mediated rare-spin correlation spectroscopy in rotating solids.

Author information

1
Max-Planck-Institute for Biophysical Chemistry, Solid-State NMR, Department for NMR-based Structural Biology, Am Fassberg 11, 37077 Göttingen, Germany.

Abstract

A novel solid-state NMR concept is introduced that allows for the detection of through-space proton-proton contacts in high spectral resolution. The proposed method not only can be utilized to infer sequential assignments and backbone or side chain conformation in solid-phase polypeptides, but it also provides information about the three-dimensional arrangement of the molecule of interest. As a result, the molecular structure can be studied without additional restrictions regarding sample labeling or magic angle spinning rates.

PMID:
12175218
DOI:
10.1021/ja026691b
[Indexed for MEDLINE]

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