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Monaldi Arch Chest Dis. 2002 Feb;57(1):48-64.

Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far.

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Thoracic Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Dovehouse Street, London SW3 6LY, United Kingdom.


The beginning of the 1990s saw the synthesis and evaluation of orally-active, second generation phosphodiesterase (PDE) inhibitors that have high specificity for the PDE4 subtype. In vitro and in vivo studies established that this class of compounds suppresses the activity of many pro-inflammatory and immune cells indicating that they may be effective in the treatment of airway inflammatory diseases. In this article we review the development status of the most advanced and extensively studied PDE4 inhibitors for asthma and chronic obstructive pulmonary disease.

[Indexed for MEDLINE]

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