Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2002 Sep 1;35(Suppl 1):S6-S16.

Gastrointestinal microflora studies in late-onset autism.

Author information

1
Infectious Diseases Section, Veterans Affairs Medical Center, West Los Angeles, CA, USA. sidfinegol@aol.com

Abstract

Some cases of late-onset (regressive) autism may involve abnormal flora because oral vancomycin, which is poorly absorbed, may lead to significant improvement in these children. Fecal flora of children with regressive autism was compared with that of control children, and clostridial counts were higher. The number of clostridial species found in the stools of children with autism was greater than in the stools of control children. Children with autism had 9 species of Clostridium not found in controls, whereas controls yielded only 3 species not found in children with autism. In all, there were 25 different clostridial species found. In gastric and duodenal specimens, the most striking finding was total absence of non-spore-forming anaerobes and microaerophilic bacteria from control children and significant numbers of such bacteria from children with autism. These studies demonstrate significant alterations in the upper and lower intestinal flora of children with late-onset autism and may provide insights into the nature of this disorder.

PMID:
12173102
DOI:
10.1086/341914
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center