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Nat Neurosci. 2002 Sep;5(9):837-8.

A-kinase anchoring proteins in amygdala are involved in auditory fear memory.

Author information

1
W. M. Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York 10003, USA.

Erratum in

  • Nat Neurosci 2002 Oct;5(10):1017.

Abstract

A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation. Here we show that the regulatory subunits of PKA are colocalized with AKAP150 (an AKAP isoform that is expressed in the brain) in the lateral amygdala (LA) and that infusion to the LA of the peptide St-Ht31, which blocks PKA anchoring onto AKAPs, impairs memory consolidation of auditory fear conditioning.

PMID:
12172550
DOI:
10.1038/nn901
[Indexed for MEDLINE]

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