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Bioinformatics. 2002;18 Suppl 1:S189-98.

Exact genetic linkage computations for general pedigrees.

Author information

1
Computer Science Department, Technion, Haifa 32000, Israel. fmaayan@cs.technion.ac.il

Abstract

MOTIVATION:

Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models.

RESULTS:

In this paper we present algorithms for performing exact multipoint likelihood calculations on general pedigrees with a large number of highly polymorphic markers, taking into account a variety of disease models. We have implemented these algorithms in a new computer program called SUPERLINK which outperforms leading linkage software with regards to functionality, speed, memory requirements and extensibility.

PMID:
12169547
[Indexed for MEDLINE]

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