Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann Surg Oncol. 2002 Aug;9(7):668-74.

Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials.

Author information

1
Department of Surgery, University of South Florida, Tampa, FL 33601, USA.

Abstract

Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in a variety of malignancies. Pancreatic cancer is no exception; MMP-2 and MMP-9 show high levels of expression in clinical and experimental models. Inhibition of MMPs has shown great promise with synthetic inhibitors, such as BB-94, as tumorostatic agents in preclinical models, particularly when these are combined with gemcitabine. These findings have led to several clinical trials using the MMP inhibitors Marimastat and BAY12-9566. Herein, we discuss the roles of MMPs and their inhibition in pancreatic cancer.

PMID:
12167581
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center