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Can J Microbiol. 2002 Jun;48(6):479-93.

Plasmid-borne AmpC beta-lactamases.

Author information

1
Department of Clinical Microbiology, Rigshospitalet, National University Hospital, Copenhagen, Denmark. jawalras@mail.tele.dk

Abstract

Historically, it was thought that ampC genes encoding class C beta-lactamases were located solely on the chromosome but, within the last 12 years, an increasing number of ampC genes have been found on plasmids. These have mostly been acquired by ampC-deficient pathogenic bacteria, which consequently are supplied with new and additional resistance phenotypes. This review discusses the phylogenetic origin of the plasmid-encoded AmpC beta-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties.

PMID:
12166675
DOI:
10.1139/w02-039
[Indexed for MEDLINE]

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