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Sci STKE. 2002 Aug 6;2002(144):pe35.

CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?

Author information

1
Molecular Immunology Unit, Department of Immunology, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris, Cedex 15, France. fmichel@pasteur.fr

Abstract

T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.

PMID:
12165654
DOI:
10.1126/stke.2002.144.pe35
[Indexed for MEDLINE]

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