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Neuron. 2002 Aug 1;35(3):412-4.

Helping thy neighbors: spillover at the mossy fiber glomerulus.

Author information

1
Department of Neurobiology, School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Abstract

Neurotransmitter "spillover" between neighboring synapses challenges the principle of synapse specificity. In this issue of Neuron, show that release from neighboring presynaptic sites contributes significantly to AMPA receptor-mediated postsynaptic currents at cerebellar mossy fiber synapses. Unexpectedly, spillover is predicted to improve the reliability and reduce the variability of transmission at this glomerular synapse.

PMID:
12165464
[Indexed for MEDLINE]

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