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Biochem Biophys Res Commun. 2002 Aug 16;296(2):425-8.

Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction.

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Faculty of Environmental Sciences, Regional Center of Biomedical Research, University of Castilla-La Mancha, Toledo, Spain.


Aged Wistar rats are characterized by leptin and insulin resistance. The expression of SOCS-3 in hypothalamus increases with ageing. Food restriction during 3 months decreases obesity Lee index in aged rats with respect to their ad libitum aged-mates and brings serum leptin concentrations to values close to those of young rats. Food restriction partially reverts the increases in SOCS-3 mRNA levels associated with ageing. These results suggest that SOCS-3 may be a mediator of hypothalamic leptin resistance in the aged Wistar rat and that the hyperleptinemia associated with ageing is, at least in part, responsible for the increase of SOCS-3 expression in hypothalamus.

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