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Arch Otolaryngol Head Neck Surg. 2002 Aug;128(8):897-902.

Prognostic significance of p21WAF1/CIP1 expression in tongue squamous cell carcinomas.

Author information

1
Department of Otolaryngology and the Institute for Pathology, The National Hospital, University of Oslo, Norway. xin.xie@labmed.uio.no

Abstract

OBJECTIVE:

To investigate the prognostic significance of p21(WAF1/CIP1) expression and its relationship with p53 accumulation and other apoptotic markers such as Bax, Bcl-2, and apoptotic index in relation to disease-specific survival in oral tongue squamous cell carcinoma (SCC).

DESIGN:

A 10-year retrospective clinical study. Information about clinical findings, treatment, and follow-up has been recorded prospectively.

PATIENTS AND METHODS:

Diagnostic, formalin-fixed, paraffin-embedded sections taken from 80 randomly selected patients before treatment for T1 to T4 oral tongue SCC were stained immunohistochemically with p21(WAF1/CIP1). The percentages of positive nuclei that stained positive for tumor were determined.

MAIN OUTCOME MEASURES:

The significance of prognostic parameters was tested by log-rank and Kaplan-Meier methods for the univariate analysis. The Cox proportional hazards regression model was used for multivariate analysis.

RESULTS:

Expression of p21(WAF1/CIP1) correlated inversely with T classification and clinical stage (P =.02 and P =.006, respectively) but not with N classification, tumor differentiation, or apoptosis-related variables such as p53 accumulation, apoptotic index, and Bax and Bcl-2 expression. Patients with tumors expressing high p21(WAF1/CIP1) values had increased disease-specific survival time (P =.03). The correlation between p21(WAF1/CIP1) expression and disease-specific survival was even more significant when restricted to p53-negative tumors (P =.002). A 2-parameter combination between p21(WAF1/CIP1) expression and Bax expression or p21(WAF1/CIP1) expression and p53 accumulation, respectively, revealed an enhanced prognostic potential (P<.001) when compared with single parameters.

CONCLUSION:

The expression of p21(WAF1/CIP1), particularly in combination with p53 accumulation or Bax expression, has prognostic value in oral tongue SCC.

PMID:
12162767
[Indexed for MEDLINE]

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